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8 Best Mouse and Rat Urine Cleaners for Your Home in 2022 – Reviews & Top Picks

mouse up close

mouse up close

Changing seasons can bring plenty of unwanted guests, like mice and rats, into our homes. Even after we get rid of them, we need to start the difficult process of cleaning up after them. Rodents relieve themselves wherever they want to and can quickly make a mess. Their urine can also leave behind an odor. If you recently had a mouse or rat in your home and need to clean things up, keep reading as we list the best mouse and rat urine cleaners.
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A Quick Comparison of Our Favorites of 2022

Rating Image Product Details
Best Overall
Winner
Hepper Advanced Bio-Enzyme Pet Stain and Odor Eliminator Spray Hepper Advanced Bio-Enzyme Pet Stain and Odor Eliminator Spray
  • Lifts and remove stains
  • Works on any organic material
  • No fragrance
  • Best Value
    Second place
    Nature’s Miracle Cage Cleaner Nature’s Miracle Cage Cleaner
  • Destroys urine and feces
  • No fragrance
  • Easy to use
  • Premium Choice
    Third place
    URINE-B-GONE URINE-B-GONE
  • Works well
  • Non-toxic formula
  • High enzyme count
  • Rocco & Roxie Stain & Odor Eliminator Rocco & Roxie Stain & Odor Eliminator
  • Cleans well
  • Removes odors
  • Easy to use
  • AmazonCommercial Multi-Purpose Enzyme Cleaner AmazonCommercial Multi-Purpose Enzyme Cleaner
  • Works well
  • Large amount
  • The 8 Best Mouse and Rat Urine Cleaners

    1. Hepper Advanced Bio-Enzyme Pet Stain and Odor Eliminator Spray — Best Overall

    Hepper-Advanced-Bio-Enzyme-Pet-Stain-Odor-Eliminator-Spray

    Type: Enzyme cleaner
    Size: 32 ounces

    Hepper Advanced Bio-Enzyme Pet Stain and Odor Eliminator Spray is our pick as the best overall mouse and rat urine cleaner for your home. It uses powerful enzymes to destroy stains and eliminate odors. The enzymes eat any organic material that they find, including mouse and rat urine, vomit, and feces. It works on any surface, including wood or tile, but does an especially great job on fabric like carpet and upholstery. Spray it on, and a few hours later, you will notice the stain dissolving. Soon after that, it will be gone, along with any bad odor. The large container means you will have enough for several accidents, and there is no fragrance, so you won’t be simply masking the odor. We found that it works quite well and doesn’t have the high cost of many other brands.

    The only downside of using the Advanced Bio-Enzyme Pet Stain and Odor Eliminator is that it’s difficult to squeeze the trigger compared to some other spray bottles, and it leaks a bit from the nozzle.

    At House Grail, we’ve admired Hepper for many years and decided to take a controlling ownership interest so that we could benefit from the outstanding designs that look great in every home!

    Pros
    • Lifts and remove stains
    • Works on any fabric
    • Works on any organic material
    • No fragrance
    • Large container
    Cons
    • Hard to use the spray bottle

    2. Nature’s Miracle Cage Cleaner — Best Value

    Nature’s Miracle Cage Cleaner

    Type: Enzyme cleaner
    Size: 24 ounces

    Nature’s Miracle Cage Cleaner is our pick as the best mouse and rat urine cleaner for the money. It uses enzymes to destroy urine and feces at a molecular level. It contains no harsh fragrances and is safe to use around pets. The spray bottle is easy to use and enables you to get the product where you need it, so there isn’t much waste.

    The downside to Nature’s Miracle Cleaner is that it’s only good for small areas because the enzymes aren’t that strong, so it might take more than one application to remove the urine completely. The spray bottle can also start to leak and drip after a few uses.

    Pros
    • Destroys urine and feces
    • No fragrance
    • Easy to use
    Cons
    • Leaky bottle
    • Might take more than one application

    3. URINE-B-GONE — Premium Choice

    URINE-B-GONE

    Type: Enzyme cleaner
    Size: 1 gallon

    URINE-B-GONE is our premium choice mouse and rat urine cleaner. It’s perfect for someone who’s not afraid to spend extra money to get the job done quickly. It contains over 2 billion enzymes to help destroy any organic material causing stains or odors in your home. It uses a non-toxic formula that’s safe to use around children and pets, and it’s 100% biodegradable and environmentally friendly.

    URINE-B-GONE works extremely well but it’s quite expensive.

    Pros
    • Works well
    • Non-toxic formula
    • High enzyme count
    Cons
    • Expensive

    4. Rocco & Roxie Stain & Odor Eliminator

    Rocco & Roxie Stain & Odor Eliminator (1)

    Type: Enzyme cleaner
    Size: 32 ounces

    Rocco and Roxy Stain and Odor Eliminator is another great mouse and rat urine cleaner for your home. It uses powerful enzymes to destroy the organic material that makes up the urine at a molecular level. This cleaner works well to destroy urine and feces and helps you remove any stains present. It’s safe to use on any surface, and it won’t harm your pets.

    The downside is that it has a strong odor that some people might not enjoy, and it’s expensive compared to some other options available.

    Pros
    • Cleans well
    • Removes odors
    • Easy to use
    Cons
    • Expensive
    • Strong odor

    5. AmazonCommercial Multi-Purpose Enzyme Cleaner

    AmazonCommercial Multi-Purpose Enzyme Cleaner

    Type: Enzyme cleaner
    Size: 1 gallon

    The AmazonCommercial Multi-Purpose Enzyme Cleaner is a large container of enzymes that will help you power through several jobs at an affordable cost. It works well for cleaning multiple surfaces, so it’s a great choice if you need something less expensive.

    The main downside of using AmazonCommercial Multi-Purpose Enzyme Cleaner is that it doesn’t work as well as other, more expensive choices, and it has a slight mint fragrance that some people might not like.

    Pros
    • Works well
    • Large amount
    Cons
    • Not as strong as some other brands
    • Mint fragrance

    6. ANGRY ORANGE Enzyme Cleaner

    ANGRY ORANGE Enzyme Cleaner (1)

    Type: Enzyme cleaner
    Size: 32 ounces

    Angry Orange Enzyme Cleaner is a fantastic choice if you suspect that only one or two mice or rats were in your home. The enzymes work well to remove stains, but the small bottle won’t go as far as some other choices. That said, it combines the power of enzymes with citrus, which helps clean and lift dirt while leaving behind a pleasant fragrance.

    The downside of Angry Orange is that the citrus smell is a little strong and might turn some people off. The bottle can also be quite leaky.

    Pros
    • Enzymes combined with citrus
    • Easy to use
    Cons
    • Leaky bottle
    • Strong fragrance

    7. GreenFist Pet Magic Stain & Odor Remover

    GreenFist Pet Magic Stain & Odor Remover (1)

    Type: Enzyme cleaner
    Size: 1 gallon

    GreenFist Pet Magic Stain & Odor Remover is an environmentally friendly enzyme-based urine remover that works quite well. It’s safe to use around kids and pets and doesn’t have a strong odor like many other brands, and the large container makes it possible to tackle many jobs without needing a refill.

    The problem with the GreenFist brand is that it can take several applications to remove the odor completely.

    Pros
    • Large container
    • No odor
    Cons
    • May take several applications

    8. No Scent Small Animal — Professional Pet Waste Odor Eliminator & Cleaner

    No Scent Small Animal

    Type: Enzyme cleaner
    Size: 2 ounces

    No Scent Small Animal — Professional Pet Waste Odor Eliminator & Cleaner is an enzyme cleaner targeted at small animals like hamsters, guinea pigs, and mice. As the name suggests, there’s no bothersome fragrance and it’s 100% biodegradable. It uses a special formula that targets the high amounts of cellulose in small animal urine to help destroy the smell.

    No Scent works well, but the small bottle doesn’t go that far. There are also no ingredients listed on the bottle, so it’s hard to know if it’s safe to use around other pets.

    Pros
    • Works well
    • Biodegradable
    • Fragrance-free
    Cons
    • No printed ingredients
    • Small bottle

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    Buyer’s Guide: Selecting The Best Mouse & Rat Urine Cleaners

    How Do I Clean Up Mouse and Rat Urine?

    Wear Safety Equipment

    The first thing that you will want to do when preparing to clean up mouse and rat urine is to put on safety equipment. We highly recommend wearing rubber or vinyl gloves to protect your hands while cleaning. Safety glasses will help protect your eyes from any splashes that might occur, and a mask will protect your lungs. We also recommend opening as many windows as possible for maximum ventilation, especially if you are using a cleaner based on chemicals instead of enzymes, as it can have a strong odor.

    Use a UV Flashlight

    A UV flashlight is a perfect tool to help you locate any mouse or rat urine that may be present in your home. The urine will glow under this light, so it is easy to see, and you can track it around your home as necessary.

    Enzyme Cleaner

    We highly recommend using an enzyme cleaner to remove urine because it destroys it at a cellular level. Tiny bacteria consume it as food before dying, so the urine, stain, and odor are all destroyed. To use one of these cleaners, spray or dab a few drops onto the urine, and allow it to sit for a few minutes before wiping it off with a paper towel and discarding it. Once the area is dry again, you can use the light to see if any urine remains and repeat as necessary until it is all eliminated.

    divider 5Conclusion

    When choosing a mouse and rat urine cleaner for your home, we highly recommend Hepper Advanced Bio-Enzyme Pet Stain and Odor Eliminator Spray as it is one of the best enzyme cleaners that we’ve found, and the spray bottle makes it easy to use. Another great choice is Nature’s Miracle Cage Cleaner, as it is an inexpensive yet effective way to remove mouse and rat urine without an overpowering fragrance.


    Featured Image Credit: MainelyPhotos, Shutterstock

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